A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Applying solitary-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis interests involve:
Human Rad51 filaments on double- and one-stranded DNA: correlating regular and irregular kinds with recombination functionality.
‘It had been merely a matter of buying up a ebook on cell biology and beginning to read through. I had originate from a earth of ultra-superior vacuums, cryostats and quantum phenomena, and now I used to be Functioning at room temperature with molecular biology kits.
Sculpting nano-electrodes by using a transmission electron beam for electrical and geometrical characterization of nanoparticles.
2010, created a fresh way (‘wedging transfer’) to control nanostructures; initially report of DNA translocation as a result of graphene nanopores; and realized hybrid nanopores by directed insertion of α-hemolysin into sound-condition nanopores
Cornelis (Cees) Dekker (Haren, 7 april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en met 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
A lot of linked developments adopted, wherever our team recognized distinctive transistor variants such as one-electron transistors at home temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled multiple transistors into tiny proof-of-principle electronic circuits.
Dynamic ParB–DNA interactions initiate and manage a partition condensate for bacterial chromosome segregation
Let's say, rather than using traditional major-down silicon electronics, transistors might be created from the bottom up using single organic molecules as the switching factors? This concept, which became The premise of now’s subject of molecular electronics, very first emerged within the nineteen seventies.
Resolving the move size in condensin-pushed DNA loop extrusion identifies ATP binding since the stage-generating system
‘The idea that You can find this kind of issue being a beginning, a big bang, is now a fascinating signpost to take into account that there was a creator. But a lot more usually, and on the basis of pure rationality, I also get ceesdekker there at a Christian interpretation of reality. An atheistic worldview is usually a naturalistic worldview: basically, you'll find only atoms and natural forces that we can easily evaluate.
2001, discovery of solitary-electron transistors at room temperature based upon nanotubes; realization of 1st logic circuits with carbon nanotube gadgets; and discovery of your molecular framework of DNA restore enzymes with AFM
Developments in nanotechnology while in the 1990s built making electronic devices from solitary molecules a chance. Cees Dekker recounts how his team established a area-temperature transistor according to only one carbon nanotube.
2004, discovery of latest physics in translocation of DNA through nanopores; to start with experimental examine of ions conduction in nanofluidic channels; 1st electrochemistry with personal single-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; initial electrical docking of microtubules on kinesin-coated nanostructures; first biophysics characterization with the mechanical Homes of double-stranded RNA; and initial one-molecule examine of DNA translocation by a restriction-modification enzyme.